On June 28, 2017, the Los Angeles Clippers acquired Williams, Patrick Beverley, Sam Dekker, Montrezl Harrell, Darrun Hilliard, DeAndre Liggins, Kyle Wiltjer and a 2018 first-round pick from the Houston Rockets in exchange for Chris Paul. On November 27, 2017, Williams scored a season-high 42 points in a 120–115 win over the Los Angeles Lakers. On December 9, 2017, he hit a go-ahead pull-up 3-pointer with 1. 2 seconds remaining, lifting the Clippers to a 113–112 victory over the Washington Wizards. He finished with 35 points to lead a dominant bench effort for the Clippers. On December 31, 2017, he scored 40 points off the bench in a 106–98 win over the Charlotte Hornets. Williams was subsequently named Western Conference Player of the Week for games played Monday, December 25 through Sunday, December 31. On January 10, 2018, he scored 27 of his career-high 50 points in the third quarter of the Clippers' 125–106 win over the Golden State Warriors. He shot 16 for 27 with a career-best eight 3-pointers and made all 10 of his free throws. It was the highest scoring effort by any Clipper in a single game since Charles Smith tied a franchise record with 52 points in December 1990. Williams was subsequently named Western Conference Player of the Week for games played Monday, January 8 through Sunday, January 14.