Variety announced on August 2, 2006, that Dushku would co-star with Macaulay Culkin in Sex and Breakfast, a dark comedy written and directed by Miles Brandman. A reviewer described Dushku as "charming" and giving the character "an edge". The movie was released in Los Angeles on November 30, 2007, and on DVD on January 22, 2008. She starred in Open Graves, a 2008 horror-thriller about a satanic game co-starring Mike Vogel. She played the main character in The Thacker Case and The Alphabet Killer, both thrillers based on real-life events, one of them directed by Rob Schmidt, with whom she had worked on Wrong Turn. Both movies were released in 2008. The Alphabet Killer contains Dushku's first topless scene. The film earned mixed reviews, but reviewers praised Dushku's performance, commenting "Eliza Dushku commands the screen but cannot reconcile the script's conflicted and increasingly idiotic agendas. " She appeared in Bottle Shock, a drama about Napa valley wine. The film was directed by Randall Miller, who helmed Nobel Son.